Protein Modification Reagents
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 100 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Creative Pegworks 4-Arm PEG-Dopamine, MW 20k - 1g
4-Arm PEG-Dopamine has 4 dopamine molecules attached to the four arms through an amide bond. Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. On the chemical side, polydopamine is polymerized dopamine that is formed from a slightly basic dopamine solution in the presence of oxygen, and it is a bioinspired material from adhesive polyphenolic proteins in mussels.
Medchemexpress LLC Alkyne-cRGD | 2665674-77-9 | 99.5% | 713.78 | 1 MG
Alkyne-cRGD is an integrin ligand that can be used in the study of degraders and undergoes copper-catalyzed azide-alkyne cycloaddition reaction.
- Integrin ligand
- Used in the study of degraders
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction
eMolecules 1844894-82-1 | t-Boc-Aminooxy-PEG1-amine | Broadpharm220.269 | C9H20N2O4 | 98.000 | CC(C)(C)OC(=O)NOCCOCCN | 250mg | 368397708
t-Boc-Aminooxy-PEG1-amine | Broadpharm | 1844894-82-1220.269 | C9H20N2O4 | 98.000 | CC(C)(C)OC(=O)NOCCOCCN | 250mg | 368397708
eMolecules Medchem Express | N3-PEG3-vc-PAB-MMAE | 5mg | 446256235 | HY-100874 | MFCD31382118 | 1352.684 | C67H109N13O16
Medchem Express | N3-PEG3-vc-PAB-MMAE | 5mg | 446256235 | HY-100874 | | MFCD31382118 | 1352.684 | C67H109N13O16
Medchemexpress LLC Cholesterol-PEG-maleimide | 95.1% | 2000 Da (average) | 50 MG
Cholesterol-PEG-maleimide (average MW 2000) is a cholesterol-terminated polyethylene glycol with a terminal maleimide group. It is a solid PEGylated lipid that self-assembles in water and is used to prepare liposomes, nanoparticles, and to conjugate thiol-containing molecules via stable thioether bonds.
- Maleimide-functionalized PEG for thiol-specific conjugation.
- Average molecular weight 2000 Da provides steric stabilization and PEGylation.
- Solid powder form suitable for liposome and nanoparticle formulation.
- Enables formation of stable thioether linkages with thiol-containing molecules.
- Storage as powder at -20°C supports long-term stability.
Medchemexpress LLC PC DBCO-PEG4-NHS ester | 2055025-02-8 | MFCD30458047 | 96.9% | 945.96 | C47H55N5O16 | 5 MG
PC DBCO-PEG4-NHS ester is a PEG-based click chemistry linker reagent designed for bioconjugation and surface modification. The molecule combines a dibenzocyclooctyne (DBCO) moiety for copper-free click reactions with an NHS ester that reacts readily with primary amines, enabling efficient attachment to peptides, proteins, and other biomolecules.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC).
- NHS ester reacts with primary amines to form stable amide bonds.
- PEG4 spacer improves solubility and reduces steric hindrance.
- High purity suitable for research use and sensitive conjugation workflows.
- Stable when stored cold and protected from moisture to maintain reactivity.
eMolecules 2141981-87-3 | TCO-PEG2-amine | Broadpharm300.399 | C15H28N2O4 | 95.000 | NCCOCCOCCNC(=O)OC1CCC\C=C\CC1 | 100mg | 433947015
TCO-PEG2-amine | Broadpharm | 2141981-87-3300.399 | C15H28N2O4 | 95.000 | NCCOCCOCCNC(=O)OC1CCC\C=C\CC1 | 100mg | 433947015
Medchemexpress LLC Azido-PEG4-beta-D-glucose | 1609083-15-9 | 99.9% | 381.38 | C14H27N3O9 | 5 MG
Azido-PEG4-beta-D-glucose is an azide-terminated PEG4 linker bearing a beta-D-glucose moiety, designed for use in click chemistry and PROTAC linker synthesis. It facilitates bioconjugation via copper-catalyzed and strain-promoted azide-alkyne cycloaddition and is supplied as a high-purity, well-characterized small-molecule linker for research applications.
- Contains an azide functional group compatible with CuAAC and SPAAC reactions.
- Incorporates a beta-D-glucose unit to increase hydrophilicity and potential targeting.
- PEG4 spacer provides flexible linker length for conjugation strategies.
- High purity suitable for research and bioconjugation workflows.
- Supplied in small quantities for synthetic and analytical use.
Medchemexpress LLC Aminooxy-amido-PEG4-propargyl | 2253965-03-4 | 97.0% | 304.34 | C13H24N2O6 | 100 MG
Aminooxy-amido-PEG4-propargyl is a PEG4 linker bearing an aminooxy group and a terminal propargyl (alkyne) functionality. It is used as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition and as a non-cleavable spacer in antibody-drug conjugate and bioconjugation chemistry.
- Molecular weight 304.34.
- Purity 97.0%.
- Chemical formula C13H24N2O6.
- CAS number 2253965-03-4.
- Available in 100 MG and other pack sizes.
- Suitable for CuAAC click chemistry and bioconjugation.
Medchemexpress LLC THP-PEG4-Pyrrolidine(N-Me)-CH2OH | 2378261-81-3 | 95.0% | 50 MG
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker. This compound is used in the synthesis of PROTACs, which are molecules designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. PROTACs achieve this by connecting two ligands: one for an E3 ubiquitin ligase and another for the target protein, offering a novel approach in biological activity modulation.
- Functions as a PROTAC linker
- Facilitates selective protein degradation
- Useful for biological research applications
- Available with comprehensive documentation
Nanocs Thiol carboxylic PEG, HS-PEG-COOH | 100mg
Thiol carboxylic PEG, HS-PEG-COOH | MW: 1000 | 100mg
Medchemexpress LLC (2R)-3-(((2-(2-azidoacetamido)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate | 2839508-98-2 | 96.4% | 831.11 | C43H83N4O9P | 10 MG
DSPE-N3 is an azide-functionalized phospholipid (C43H83N4O9P; CAS 2839508-98-2) intended for research use. It provides an azide handle for covalent conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition, enabling facile functionalization of liposomes, nanoparticles, and surfaces.
Medchemexpress LLC OSu-PEG4-VC-PAB-MMAE | 1mg
OSu-PEG4-VC-PAB-MMAE involves in GDP-FAmP4MMAE (Monomethylauristatin E) synthesis which is for GDP label via site-specific conjugation[1]